Effect of patient inhalation profile and airway structure on drug deposition in image-based models with particle-particle interactions
Published in International Journal of Pharmaceutics, 2022
Recommended citation: Williams, J., Kolehmainen, J., Cunningham, S., Ozel, A. and Wolfram, U., 2022. Effect of patient inhalation profile and airway structure on drug deposition in image-based models with particle-particle interactions. International Journal of Pharmaceutics, 612, p.121321. https://www.sciencedirect.com/science/article/abs/pii/S0378517321011273
Highlights:
Regional and local drug deposition was modelled in three patients during normal, sinusoidal inhalation and an exacerbation.
Local drug deposition changes with airway shape and inhalation profile, even when regional deposition is similar.
Image-based models were combined with highly-resolved particle tracking including particle contact and cohesion.
Fluid model validated by comparing gas velocity field with in vitro experiments.